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1.         A woman with blood group A gave birth to twins both having blood group AB.                

            Determine the genotype of:

            a) Father                     

            b) Mother                                                                                                                               

2.         50 black mice and 50 white mice were released into an area inhabited by a pair of owls. After four

            months, the mice in the area were recaptured and only 38 of the black mice and 9 of the white

            mice were remaining.

            a) How would this observation be explained ?                                                                      

            b) Name the theory of evolution that supports the results in (a) above.                                 

3.         State three mechanisms that prevent self pollination in a flower that has both male and female

            Parts.                                                                                                                                      

4.         (a) Distinguish between complete and incomplete dominance                                             

            (b) State two sources of variation                                                                                          

5.         Part of one strand of a DNA molecule was found to have the following base sequence.     

                G – T – C – A – G – T

            (a) What is the sequence on m-RNA strand copied from this DNA portion?                       

(b) State two roles of DNA molecule.

6.         State three ways by which plants compensate for lack of ability to move from one place to

another.                                                                                                                                  

7.         A student mixed a sample of urine from a person with Benedict’s solution and heated, the colour

changed to orange.

(a) What was present in the urine sample?                                                                            

(b) What did the student conclude on the health status of the person?                                 

(c) Which organ in the person may not be functioning properly?                                         

8.         Differentiate between continuous and discontinuous variations                                           

9.         Members of the same species of organism tend to differ due to variation. State three causes of

             variation in organisms

10.       Identify the type of gene mutations represented by the following pairs of words:-              

            (i) Shirt instead of skirt                      

            (ii) Hopping instead of shopping       

            (iii) Eat instead of tea              

11.       A DNA stand has the following base sequence:        GCCTAGATCAC
            What is the sequence of the :              (i) Complementary DNA strand?                                          

                                                                        (ii) M-RNA strand coped form this DNA strand                  

12.       The figure below represents the distribution of height of pupils in a school

          (a) Name the type of variation represented by the curvein man

             

13.       a) Wekesa and Wanjiku who are siblings are  both normal as their parents but  have a hemophilic

                 brother. Give the Genotype of their parents.                                                                                

            b) i)What are linked genes?                                                                                                   

                ii) What do you understand by the phase a test cross?                                                      

14.       There are at least 205 known sex – linked recessive disorder                                              

            a) Name any two of them.                                                                                                     

            b) State a reason why sex – linked recessive why traits tend to effect the male child.

            c) State why if a mother has the trait all her sons will have it

15.       The table below is a representation of a chromatide with genes along its length. It undergoes

mutation to appear as shown below:                                                                                      

 Before mutationLMNOPQ
After  mutationLONMPQ

a) Name the type of chromosomal mutation represented      

b) Name one mutagenic agent                                                                                                           

16.       The figure below is a structural diagram of a portion from a nucleic acid strand                

a) Giving a reason, name the nucleic acid to which the portion belongs                                          

            b) Write down the sequence of bases of a complementary DNA strand                                          

17.       In an experiment, plants with red flowers was crossed with plants with white flowers.      

            All the plants in the F1 generation had pink flowers.

            a) Give a reason for the appearance of pink flowers in the F1 generation                            

            b) If plants in F1 were selfed, state the phenotypic ratio of the F2 generation                                    

            c) Explain;       i) Why women should drink extra milk during pregnancy                                       

                                    ii) A pregnant women might want to urinate more often in late pregnancy             

18.       State the meaning of the following terms giving an example in each case:

            (a) Sex-linked genes                                                                                                  

            (b) Multiple alleles                                                                                                                             

19.       In a certain breeding experiment, a plant species with red flowers was selfed. It produced 119

            red   flowered and 41 white flowered offsprings.                                                                            

            (a) Using letter R to represent allele for the red flowers, state the genotype of the red flowered

                        parent plant                                                                                                                            

            (b) Determine the phenotypic ratio of red and white flowered plants. Show your working 

20.       Give an example of a sex-linked trait in human on:                                                                           (i) Y – Chromosome           

            (ii) X – Chromosome        

21.       Explain why growth of long hair on the pinnae of the ears in human occurs in males only

22.       Explain why prophase 1 of meiosis contributes towards genetic variation in living           

           organisms.

23.       A pure Red flowered plant was crossed with a pure white flowered plant. All the F1 generation

            plants had pink flowers.                                                                                                         

            (a) Give an explanation for the absence of Red and white flowered plants in the F1 generation.    (b) If the F1 generation pea plants were selfed, state the phenotypic ratio of the F2 generation

                  plants.                                                                                                                               

24.       (a) Name a genetic disorder due to gene mutation that affects the malpighian layer of the

                skin in man.                                                                                                                       

            (b) Give two functions of the fluid produced by sebaceous glands.                                     

25.       (a) Define the term “Gene mutation.”                                                                                   

            (b) Name the genetic disorders that result from gene mutation in human beings.                

26.       (i) What are mutations                                                                                                          

            (ii) Name two mutagens                                                                                                        

27.       A section of a DNA strand contains the following sequence CGGATAC

            (a) Write the;  (i) Complementary DNA strand                                                                                

                                    (ii) MRNA strand                                                                                                      

        (b) Name the site for protein synthesis in a cell                                                                                      

28.       In a certain bird species, red flight feathers is controlled by gene R while white flight feathers is

            controlled by gene r. The heterozygous condition Rr results into pink flight feathers.  The two

             genes are also sex linked and transmitted on x-chromosome.

            a) By use of fusion lines, find the genotypes of across between a male with pink flight 

                feathers and a female with white flight feathers                                                                

            b) Which type of dominance is illustrated here?       

            c) i)Identify  the  nucleic acid  whose base sequence is  shown below:                                

                   G-A-C-U-A-G-A-C-G

                 ii) Give a reason for your answer in c (i) above                                                               

                iii) If the nucleic acid was involved in protein synthesis, how many amino acids would be

                      present in the  protein  synthesized? Give a reason                                                     

29.       Study the genetic chart below showing the inheritance of the gene responsible for haemophilia in a family.

a) Write the genotype of individuals A, B, F                                                                                    

            b) A member of this family labelled F marries a haemophiliac male. What will be the phenotypic

 ratio of the offspring? Show your workings             

c) Other than the condition stated above, state any other two common genetic disorders that

    result from gene mutation.                                                                                                 

30.       Haemophilia is due to a recessive gene. The gene is sex-linked and located on X chromosome.

            The chart below represents the offspring of parents who are phenotypically normal for          haemophillia

(i) What are the parental genotypes?                                                                                     

                 Explain your answer in (i) above                                                                                      

            (ii) Work out the genotypes of the offspring                                                                         

31.       A cross between a red-flowered and a white flowered plant produced only pink –flowered

            F1 plants

            (a) There was neither a red nor white –flowered F1 plants. Explain                                     

           (b) The F1 offspring were selfed to get F2 generation. Using appropriate letter symbols, work

                 out the genotypes of F2 generation                                                                                               

(c) Give the genotypic and phenotypic ratios of F2 generation                                             

(d) Distinguish between dominant and recessive genes                                                                    

32.       A true-breeding purple maize variety was cross-pollinated with a true-breeding yellow

            maize  variety.

            The offspring produced all purple fruits.                                                                               

            The plants grown from these F1 grains were interbred among each other.

            A typical cob of F2 generation is shown below:

      The yellow fruits are shaded while the purple ones are un-shaded.

(a) (i) In terms of flowers only, state why it is easier to work out genetic crossings using maize   

                     (ii) Count separately the yellow and purple grains and therefore find the rations of purple

                          grains to yellow grains                                                                                                             

            (b) Using appropriate symbol, work out a genetic cross for F2 generation                           

            (c) From the above information, give the dominant gene                                                                       

            (d) State two practical applications of genetics in identity determination    

33.       The figure below is a pedigree chart showing incidence of albinism which is transmitted through a recessive gene-a. Study and answer questions that follow;

(a) Write down the genotype of persons 1 and 2. Give a reason for your answer                

           (b) Giving your reason state the most likely genotype of person 3                                       

            (c) The cross between person 15 and 16 represents mating between first cousins. Comment

                 why it is not advisable for close relatives to marry                                                          

            (d) Apart from albinism name two other effects of gene mutation                                       

34.       The table below shows results of test to determine blood groups of persons Y and Z.A tick ()

            Represents, agglutination while a cross (x) represents no agglutination;                              

PersonTest with antibody (a)Test with antibody (b)Test with Rhesus antibodyBlood group
Y- (male)       √   X          √   
X- (female)   X        X                            


            (a) Fill the blank space in table to show the blood group of the persons Y and Z                 

            (b) In order to investigate the inheritance of Rhesus factor, work out a cross between a male

                 with  Rh+ and female with Rh .Let D represent the presence of Rhesus factor and d to

                 represent the absence of the Rhesus factor

            (c) Determine the genotype of the cross in (b) above.                                                          

            (d)Which of the children can donate blood to their mother?                                                

35.       Describe the behavioural adaptations of animals to temperature                                          

36.       In man blood group inheritance is controlled by multiple alleles in which allele A is co dominant 

            to allele B. a  woman  laterozygous  for blood  group A  married  a man  heterozygous  for blood 

            group B

            a) State the genotype of both parents                                                                                    

            b) Using a pun net square, show the genotypes of F1 generation                                          

            c) State one application of knowledge of blood group inheritance in man                           

            d) The nitrogenous bases in nucleic acids are Adenine (A), cytosine(C), Guanine (G),

                 Thiamine (T) and uracil (U). Input of a molecule of DNA the sequence of bases is CTT.

                 Using   the letters A, C, G, T, U where appropriate, write down the base sequence in;

                 i) Corresponding part of the complementary strand of DNA molecules                         

                 ii) Corresponding part in mRNA                                                                                      

                iii) A change in the DNA molecules caused the base sequence in the triplets to change from

                     CTT to CAT.  State one factor which could have caused the change                          

37.       In an investigation plants with red flowers were crossed with plants with white flowers. All the

            plants in the F1 generation had pink flowers when the F1 plants were crossed, he counted 480

            plants in F2 generation                                                                                                           

            (a) Using appropriate letter symbols, work out the cross between the F1 plants to get the F2

     generation                                                                                                                         

            (b) Give the phenotypic and genotypic ratios for the F2 generation                                      

                 Phenotypic ratio

                 Genotypic ratio

            (c) How many plants in the F2 generation had pink flowers? (show your work)                  

38.       In an experiment, a black mouse was mated with a brown mouse. All the off springs in F1

generation were black. The off springs grew and were allowed to mate with one another. The total

number of F2 generation offspring were 96.

            (a) Using letter B to denote the gene for black colour. Work out the genotype of the F1 generation.

                  (Use a punnet square)                                                                                                                  

            (b) State the following for the F2 generation

                (i) Genotypic ratio                                                                                                             

                (ii) Phenotypic ratio                                                                                                                       

                (iii) The total number of brown mice

39.       (a) Distinguish between Homologous structures and analogous structures. Give an example

                  in each case.                                                                                                                     

                  Homologous structures

                   Example            

                  Analogous structures      

                  Example      

            (b) Explain why parasites develop resistance to certain drugs after a long time of exposure.

           (c) (i) What is non— disjunction?                                                                                          

                  (ii) Give one example of a genetic disorder associated with non-disjunction     .